![]() Parameter estimates, their precision (standard errors), and model predictions were compared a difference of 1% or less was considered “agreement”. The total number of attempted comparisons between SAAM II and PCNonlin was 161, of which 142 executed without problems. We compared 88 different models, many of them in different configurations, e.g., different weighting schemes or different parameter limits. Maximum number of compartments, data sets, and parameters were 9, 5, and 10, respectively. Models investigated included one- and multicompart-ment models with nonlinearities, multiple inputs and samples, multiple simultaneous experiments, and linear equations. Models were initially executed in PCNonlin or WinNonlin and automated comparisons with SAAM II made using Microsoft Test. For each model, both software packages were presented with identical implementations. This paper presents a detailed comparison of the kinetic analysis software packages SAAM II and PCNonlin/WinNonlin, based on benchmark modeling problems reported in “ Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications” (Gab-rielsson and Weiner, 1994) and seven additional models.
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